Weiterbildungsbefugnisse

  • Innere Medizin und/oder Allgemeinmedizin / Basisweiterbildung / 36 Monate / LÄK Hamburg / WBO 05 /
  • Innere Medizin und/oder Allgemeinmedizin / Kardiologie / 36 Monate / LÄK Hamburg / WBO 05 /
  • Zusatzweiterbildung / Intensivmedizin / 12 Monate / LÄK Hamburg / WBO 05 /

Kurzvita

Höhepunkte der beruflichen Laufbahn

  • 2005 Oberarzt, Herzkatheter Franz-Volhard-Klinik, Charité Campus Buch, Berlin
  • 2008 stellvertretender Leiter & Leitender Oberarzt Abt. Kardiologie, Asklepios Klinik St. Georg
  • 2014 Gesellschafter Cardiologicum Hamburg
  • 2014 Leiter des Katheterlabors Cardiologicum / Asklepios Klinik Wandsbek
  • 2016 Konsiliararzt Abt. Kardiologie, Asklepios Klinik St. Georg
  • 2019 Chefarzt Abt. Innere Medizin Kardiologie/Pneumologie Asklepios Klinik Wandsbek
  • 2020 Chefarzt Kardiologie, Pneumologie & internistische Intensivmedizin, Asklepios Klinik Altona

Universitäre Ausbildung

  • 1993 Studium der Humanmedizin Christian-Albrechts-Universität zu Kiel
  • 1996 AiP/wissenschaftlicher Assistent, I. Medizinische Universitätsklinik Christian-Albrechts-Universität zu Kiel
  • 1998 Ausbildungsstipendium Deutsche Forschungsgemeinschaft
  • 1998 DFG Forschungsstipendium
  • 2004 wissenschaftlicher Assistent, Franz-Volhard-Klinik, Charité Campus Berlin-Buch, Prof. Dr. Rainer Dietz, Prof. Dr. Friedrich Luft & Prof. D. Ganten
  • 2005 Helmholtz-Stipendiat

Mitgliedschaften in medizinischen Fachgesellschaften

  • Arbeitsgruppe Interventionelle Kardiologie der DGK
  • Deutsche Gesellschaft für Kardiologie
  • European Association of Percutaneous Cardiac Interventions (EAPCI)
  • Faculty EuroPCR Course
  • Faculty Transcatheter Cardiovascular Therapeutics (TCT)
  • Klinische Kommission der Deutschen Gesellschaft für Kardiologie

Weitere Qualifikation

  • Fellow der European Society of Cardiology
  • Zusatzbezeichnung spezielle, internistische Intensivmedizin
  • Zusatzqualifikation Herzinsuffizienz
  • Zusatzqualifikation interventionelle Kardiologie

Forschung & Lehre

Wissenschaftliche Interessen

  • Grundlagenforschung Herzinsuffizienz und kardiale Regeneration
  • Grundlagenforschung molekulare Signaltransduktion
  • Interventionelle Kardiologie: PCI & invasive Bildgebung
  • Strukturelle Herzerkrankungen: TAVI, LAA-Verschluss, inter-atriale Shunts

Wissenschaftliche Auszeichnungen und Preise

  • 2007 Winterstein Preis der Deutschen Herzstiftung
  • 2013 Forschungspreis der Asklepios Kliniken
  • European Socienty of Cardiology

Weitere Publikationen

  • Analysis of Immunoglobulins in Sarcoidosis
  • Evidence for involvement of NF-B in the transcriptional control of COX-2 gene expression by IL-1
  • B degradation and nuclear factor-B DNA binding are insufficient for interleukin-1 and tumor necrosis factor- induced B-dependent transcription
  • Effect of dexamethasone on IL-1 -induced NF-B and B-dependent transcription in epithelial cells
  • Gene expression of profibrotic mediators in bronchiolitis obliterans syndrome after lung transplantation
  • Repression of COX-2 and PGE2 Release by Dexamethasone Occurs by Transcriptional and Post-transcriptional Mechanisms Involving Loss of Polyadenylated mRNA
  • Molecular Regulation of Granulocyte-Macrophage Colony-Stimulating Factor in Human Lung Epithelial Cells by Interleukin (IL)-1beta, IL-4, and IL-13 Involves Both Transcriptional and Post-Transcriptional Mechanisms
  • Stimulus-specific inhibition of IL-5 by cAMP-elevating agents and IL-10 reveals differential mechanisms of action
  • Adenosine 3',5'-Cyclic Monophosphate (cAMP)-Dependent Inhibition of IL- 5 from Human T Lymphocytes Is Not Mediated by the cAMP-Dependent Protein Kinase A
  • Effect of NF- kappa B Inhibition on TNF- alpha -induced Apoptosis and Downstream Pathways in Cardiomyocytes
  • GM-CSF expression in pulmonary epithelial cells is regulated negatively by posttranscriptional mechanisms
  • In Cardiomyocyte Hypoxia, IGF-I-Induced Antiapoptotic Signaling Requires PI3-kinase- Dependent and MAPK-Dependent Activation of the Transcription Factor CREB
  • Evidence for post-transcriptional regulation of interleukin-5 by dexamethasone
  • IL-1beta-dependent activation of NF-kappaB mediates PGE2 release via the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase
  • . Dexamethason inhibits T-cell GM-CSF release independent of NF-B. Role of post-transcriptional mechanisms
  • Glucocorticoid inhibition of GM-CSF from T cells is independent of control by NF-{kappa}B and CLE0
  • Reoxygenation after severe hypoxia induces cardiomyocyte hypertrophy in vitro: Activation of CREB downstream of GSK3
  • Statins inhibit cardiomyocyte apoptosis by inhibition of GSK3: stabilization of -catenin
  • Requirement of NF-B in angiotensin II- and isoproterenol- induced cardiac hypertrophy in vivo
  • -catenin downregulation is required for adaptive cardiac remodeling
  • Beta-Catenin downregulation attenuates ischemic cardiac remodeling through enhanced resident precursor cell differentiation
  • MEF2 transcriptional activity maintains mitochondrial adaptation in cardiac pressure overload
  • NF-{kappa}B activation is required for adaptive cardiac hypertrophy
  • Intracoronary compared with intravenous bolus abciximab application during primary percutaneous coronary intervention: Design and rationale of the abciximab intracoronary versus intravenously drug application in st-elevation myocardial infarction (aida stemi) trial
  • Chronic, low-dose epoetin- following PCI attenuates left ventricular remodeling in patients with ischemic cardiomyopathy
  • Krueppel-like factor 15 regulates Wnt/β-catenin transcription and controls cardiac progenitor cell fate in the postnatal heart
  • Delivery of a bioresorbable vascular scaffold to complex lesions
  • New technical and anticoagulation aspects for left atrial appendage closure using the WATCHMAN device in patients not taking warfarin
  • Percutaneous left-ventricular support with the impella-2.5-assist device in acute cardiogenic shock: Results of the impella-euroshock-registry
  • The four and a half lim-domain 2 controls early cardiac cell commitment and expansion via regulating beta-catenin-dependent transcription
  • Cardiac tamponade due to coronary perforation during percutaneous interventions successfully treated with microspheres
  • Left atrial appendage closure for stroke prevention in non-valvular atrial fibrillation: rationale, devices in clinical development and insights into implantation techniques
  • Percutaneous left atrial appendage closure in patients with left atrial appendage thrombus
  • Results of the ALSTER BP Real World Registry on renal denervation employing the SYMPLICITY system
  • Risk factors for clinical events at 1-year follow-up after drug-eluting stent implantation: results from the prospective multicenter German DES.DE registry
  • EWOLUTION: Design of a registry to evaluate real-world clinical outcomes in patients with AF and high stroke risk-treated with the WATCHMAN left atrial appendage closure technology
  • Meta-Analysis of Cell-based CaRdiac stUdiEs (ACCRUE) in patients with acute myocardial infarction based on individual patient data
  • Multimodality Intra-Arterial Imaging Assessment of the Vascular Trauma Induced by Balloon-Based and Nonballoon-Based Renal Denervation Systems
  • Percutaneous left atrial appendage closure in patients with left atrial appendage thrombus
  • Twelve-month results of the rapid renal sympathetic denervation for resistant hypertension using the OneShotTM ablation system (RAPID) study
  • Very Late Scaffold Thrombosis Due to Insufficient Strut Apposition
  • Delayed coverage of drug-eluting stents after interventional revascularisation of chronic total occlusions assessed by optical coherence tomography: the ALSTER-OCT-CTO registry
  • Implant success and safety of left atrial appendage closure with the WATCHMAN device: peri-procedural outcomes from the EWOLUTION registry
  • Implant success and safety of left atrial appendage closure with the WATCHMAN device: peri-procedural outcomes from the EWOLUTION registry
  • Safety and efficacy of lesion preparation with the AngioSculpt Scoring Balloon in left main interventions: the ALSTER Left Main registry
  • Clinical Cases in LAA Occlusion
  • Improved Algorithm for Ostium Size Assessment in Watchman Left Atrial Appendage Occlusion Using Three-Dimensional Echocardiography
  • Investigators E. Efficacy and safety of left atrial appendage closure with WATCHMAN in patients with or without contraindication to oral anticoagulation: 1-Year follow-up outcome data of the EWOLUTION trial
  • Oral anticoagulation and platelet inhibition after atrial appendage occlusion
  • The Assessment of the Watchman Device in Patients Unsuitable for Oral Anticoagulation (ASAP-TOO) trial
  • Trends Cardiovasc Med
  • European registry data on LAA closure: advancing the field of interventional stroke prevention
  • European registry data on LAA closure: advancing the field of interventional stroke prevention
  • Incidence of pericardial effusion after left atrial appendage closure: The impact of underlying heart rhythm-Data from the EWOLUTION study
  • Incidence of pericardial effusion after left atrial appendage closure: The impact of underlying heart rhythm-Data from the EWOLUTION study
  • Optical coherence tomography-guided versus angiography-guided implantation of everolimus-eluting bioresorbable vascular scaffolds: Comparison of coverage, apposition and clinical outcome
  • Real-world safety and efficacy of WATCHMAN LAA closure at one year in patients on dual antiplatelet therapy: results of the DAPT subgroup from the EWOLUTION all-comers study
  • Real-world safety and efficacy of WATCHMAN LAA closure at one year in patients on dual antiplatelet therapy: results of the DAPT subgroup from the EWOLUTION all-comers study
  • Three-months optical coherence tomography analysis of a biodegradable polymer, sirolimus-eluting stent
  • Evaluating Real-World Clinical Outcomes in Atrial Fibrillation Patients Receiving the WATCHMAN Left Atrial Appendage Closure Technology
  • Impact of an interatrial shunt device on survival and heart failure hospitalization in patients with preserved ejection fraction
  • Impella Support for Acute Myocardial Infarction Complicated by Cardiogenic Shock
  • Rationale and design of the European multicentre study on Stem Cell therapy in IschEmic Non-treatable Cardiac diseasE (SCIENCE)
  • The AFR-PRELIEVE trial: a prospective, non-randomised, pilot study to assess the Atrial Flow Regulator (AFR) in heart failure patients with either preserved or reduced ejection fraction
  • Antithrombotic Therapy and Device-Related Thrombosis Following Endovascular Left Atrial Appendage Closure
  • Propensity-Matched Comparison of Oral Anticoagulation Versus Antiplatelet Therapy After Left Atrial Appendage Closure With WATCHMAN
  • The atrial flow regulator: current overview on technique and first experience
  • Initial and long-term antithrombotic therapy after left atrial appendage closure with the WATCHMAN
  • Evaluation of Myocardial Gene Expression Profiling for Superior Diagnosis of Idiopathic Giant-Cell Myocarditis and Clinical Feasibility in a Large Cohort of Patients with Acute Cardiac Decompensation
  • One-year results of the first-in-man study investigating the Atrial-Flow-Regulator for left-atrial shunting in symptomatic heart failure patients: the PRELIEVE study

Aktuelle Lehrtätigkeit

  • Lehrbefugnis für das Fach Innere Medizin Charité
  • Lehrbefugnis für das Fach Innere Medizin UKE
  • Professor §117 Hamburger Hochschulgesetz

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